These include the target genes TSC2 (tuberous sclerosis complex 2) and PTEN (phosphatase and tensin homolog), both of them being determined or presumed tumor suppressors, respectively, as well as the nutrient energy sensor AMP-activated protein kinase (AMPK) or sestrins 1 and 2 that are AMPK activators [67,68,69,70]. The gene discussed is PTEN; the disease is neoplasm.