Percentage of tumor volume is significantly reduced in 4 out of 6 perturbations compared with ph505 alone (46%): 14% in ph505, cad-KD; 13% in ph505, drm-KD; 5% in ph505, kni-KD; and 14% in ph505, bgcn-KD. The gene discussed is GREM1; the disease is neoplasm.