MAPT and Alzheimer disease: We have shown that αCBSF significantly reduced Aβ and tau phosphorylation (p-tau-Thr231) in 3xTg-AD mice, whereas αCBSF enhanced α-secretase cleavage products (i.e., sAPPα and α-CTF), indicating that α-secretase-like content in CBS promotes APP nonamyloidogenic processing in vivo (Fig. 8B and C).