Of interest, the CXCR7 inhibitor CCX771 was recently described to interfere with CXCL12-directed migration of CXCR7-positive CD14+ CD16+ monocytes of HIV-infected people into the CNS, which can result in a neurodegenerative disease termed NeuroAIDS [39]. This evidence concerns the gene ACKR3 and neurodegenerative disease.