The low response rate may reflect the effects of tropical enteropathy [38] a disease of the gut that dampens immune responses to antigens and possible due to constant fecal-oral contamination, waning of gut immunity due to pre-exposure presence of maternal antibodies and presence of other enteric pathogens, interference with other vaccines, and host characteristics (e.g., genetics, level of nourishment, breastfeeding), [39, 40].- Further in our study, plasma IgA antibody response was measured at one week post second dose, there was limited time to induce antibody production on all subjects." Here, CD79A is linked to tropical sprue.