POLG and mitochondrial disease: Understanding these complex interactions and how they lead to disease is particularly pertinent given the recent development of pronuclear transfer (PNT) in the prevention of transmission of mtDNA mutations.41 Indeed, nuclear factors involved in m.3243A>G‐related disease may also impact other clinically heterogeneous mitochondrial diseases such as those caused by m.8344A>G and mutations within POLG.42, 43