Therefore, PPD-B- and CE-induced IP-10 and IL-17A mRNA expression could be used to differentiate M. bovis-infected calves from uninfected ones between 6 and 58 weeks post-infection, whereas PPD-B- and CE-induced IP-10 and IL-17A protein expression could be used to differentiate M. bovis-infected calves from uninfected ones between 6 and 30 weeks post-infection. This evidence concerns the gene CXCL10 and infection.