PDHA1 and cardiomyopathy: Since Cre-recombinase activity in cardiac myocytes can produce a potentially fatal cardiomyopathy in αMHC-MerCreMer mice (17), it is possible that the severity of the Cre-recombinase-induced cardiomyopathy was exacerbated by cardiac-specific deletion of Pdha1, explaining the accelerated mortality in Pdha1Cardiac−/− mice from Sun et al. (25).