HDAC1 and neoplasm: This was discovered in experiments exploring the ability of hyperpolarization to inhibit tumor formation in Xenopus. Transduction of this bioelectrical signal into tumor repression proceeds via Vm-modulated transport of histone deacetylase 1 (HDAC1), a factor involved in control of the cell cycle, apoptosis, and differentiation (Chernet and Levin, 2014).