INS and type 2 diabetes mellitus: Using the same clamp data, we previously showed that insulin secretion decreases from NGT to borderline type to T2DM.14,30 In this study, however, the parameters α and β, related to insulin secretion, did not show any significant differences among the NGT, borderline type, and T2DM subjects, possibly because previously defined insulin secretion30 is described by insulin secretion and delivery in this model, which depends on other parameters such as h, m, Xb, and kratio, and the parameters involved in insulin secretion and delivery are too diverse.