INS and type 2 diabetes mellitus: We previously developed a mathematical model for concentrations of plasma glucose and serum insulin measured during consecutive hyperglycemic and hyperinsulinemic-euglycemic clamps and found significant decreases in insulin secretion, sensitivity, and peripheral insulin clearance from NGT to borderline type to T2DM.30 The differences between our previous study and this study are the model structure and C-peptide data.