HAVCR2 and graft versus host disease: Although the relevance of this observation for Tim-3-mediated signaling is not well understood, Tim-3 shedding has been observed with CD14+ monocytes, in response to lipopolysaccharide stimulation, and in T cells, in the setting of graft-versus-host disease (GVHD) after allogenic hematopoietic cell transplant.