Analyses of the cytokine and chemokine profiles of children with natural measles and experimentally infected macaques early after infection suggest activation of the nuclear factor kappa B (NF-κB) (for example, interleukin-6 [IL-6], CCL2, and tumor necrosis factor alpha [TNFα]) and inflammasome (for example, NLRP3, IL-1β, and IL-18) pathways but not the IFN (for example, IFNα, IFNβ, and IFNλ) response19,20 (Figure 2). This evidence concerns the gene IFNA1 and infection.