Abnormal stimulation of the TLR4/NF-κB signaling pathway has been reported to be involved in numerous autoimmune diseases and chronic inflammation, and NF-κB have been reported to be highly expressed in several malignancies, and high expression of NF-κB was closely associated with the metastasis of carcinoma [24, 41]. This evidence concerns the gene NFKB1 and autoimmune disease.