Tell RW et al. (2014) demonstrated that p70S6K phosphorylation and JNK signaling could induce pSTAT3 formation in basal-like cancers, SRC Y527 and EGFR Y1068 phosphorylation prompt STAT3 phosphorylation in luminal A, and PKC α S657 and YB-1 S102 stimulate STAT3 phosphorylation in luminal B-type breast cancers [26]. The gene discussed is RPS6KB1; the disease is breast cancer.