In summary, the combined data from the above acute and chronic colitis experiments show that the course and severity of disease in each model are very similar, if not identical in ADAM17ex/ex and ADAM17ex/ex/RIPK3−/− mice, and strongly support the assumption that the functions of RIPK3 are dispensable for DSS-induced colitis in ADAM17 hypomorphic mice. The gene discussed is ADAM17; the disease is colitis.