Regarding a role of non-necroptotic functions of RIPK3 (such as those suggested by Moriwaki et al. [43]) in the hypersensitive response of ADAM17ex/ex mice to DSS-induced colitis, we currently do not know whether hypomorphic ADAM17 impairs only the necroptotic activation (i.e., phosphorylation) of RIPK3 or whether it also interferes with its necroptosis-independent functions. This evidence concerns the gene RIPK3 and colitis.