RIPK3 and colitis: Although pBcl-2 was not detectable for unknown reasons in ADAM17ex/ex/RIPK3−/− mice, cleaved caspase-3 displayed an increased signal in samples from DSS-treated ADAM17ex/ex mice, showing that unlike necroptosis, apoptosis is induced in ADAM17ex/ex mice in the course of acute colitis (Figure 7B).