Moreover, the proportion of Immu_Genes that correlated negatively with CD147 was also higher than the positively correlating non-Immu_Genes (9.7%, 61 of 627 Immu_Genes, compared with 3.7%, 702 of 18,901 non-Immu_Genes; P < 0.001), suggesting that the Immu_Genes may be suppressed by CD147 in cancer cell lines, and CD147 may be a negative regulator for immune response processes (Figure 3C). Here, BSG is linked to cancer.