Recently, Trimarchi T et al and Fang K et al described that LUNAR1 and ENST00000418618 lncRNAs are regulated by mutated NOTCH1 and rearrange MLL in ALL patients, respectively, indicating that such lncRNAs may have oncogenic properties in this disease [20, 21]. This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.