In ALL, recent works have identified altered lncRNAs associated to common genetic alterations, such as translocations related with the 11q23 locus (t(4:11), t(11:19), t(9:11)), that alter the function of MLL gene in B-ALL, and NOTCH1 mutations in T-ALL [20, 21, 30–32]. Here, KMT2A is linked to acute lymphoblastic leukemia.