VDAC1 and neoplasm: VDAC1 alsoplays a central role in mitochondria-mediated apoptosis by facilitating the releaseof apoptotic proteins and by association with both pro- and anti-apoptotic proteins.Tumor cells, which are constantly exposed to hypoxic conditions, affect the cell viathe transcription factor hypoxia-inducible factor (HIF) that induces transcriptionalactivity.