The bacterial clearance results of our study indicated that both IVIg treatment and cold exposure reduced bacterial clearance, and the inhibition patterns of both the groups are consistent with the results of the ITP amelioration analysis (Figure 4E; 4G, experimental outline; 4F; and 4H; the effect was observed in wild-type but not Selp−/− mice). Here, SELP is linked to autoimmune thrombocytopenic purpura.