Consistent with cold exposure, an injection of a considerable amount of menthol (1 mg/kg), a TRPM8 agonist, also suppressed ITP and bacterial clearance in wild-type mice but not in Trpm8−/− mice (Figure 7B and 7E vs. 7C and 7F, respectively). Here, TRPM8 is linked to autoimmune thrombocytopenic purpura.