Because BCD (Ighm−/−)- and P-selectin (Selp−/−)-deficient mice displayed no ITP amelioration and no suppression of bacterial clearance following cold exposure (Figures 4 and 5A–5FA), these results suggest that the cold exposure-mediated increase of cortisol and corticosterone levels is not sufficient to induce immunosuppression. Here, IGHM is linked to autoimmune thrombocytopenic purpura.