Above the basis of Ang-2 promoting lung cancer A549 cell migration and metastasis, the alterations of the EMT-related epithelial indicator (E-cadherin), mesenchymal marker (Vimentin, VIM), and transcriptional factors (Snail and Twist) expression that involved in lung cancer development were analyzed in Figure 4F and 4G. This evidence concerns the gene ANGPT2 and lung cancer.