Pearson's correlation analysis of the transmembrane cell number in the three endometrial carcinoma cells at various cisplatin doses showed strong correlation with matriptase (r = 0.874, 0.642, and 0.887 in HEC-1A, HEC-1B, and RL-952 cells, respectively; P < 0.01) and HAI-1 expression levels (r = 0 928, 0.844, and 0.779 in HEC-1A, HEC-1B, and RL-952 cells, respectively; P < 0.01). The gene discussed is SPINT1; the disease is endometrial carcinoma.