Moreover, dietary ASA significantly increase life span of the mouse villin-Cre+/−Msh2flox/flox (VpC-Msh2) LS/HNPCC intestinal cancer model [28] that displays all of the pathological hallmarks of human LS/HNPCC colorectal tumors [29]. Here, MSH2 is linked to hereditary nonpolyposis colon cancer.