The main findings of this study are as follows: PF exerts anti-neuroinflammation functions in a rat model of VD by specifically inducing CB2R function in microglia/macrophages of the hippocampus and consequently reducing the activity of the mTOR/NF-κB signaling pathway, thereby inhibiting the M1 microglia/macrophage release of proinflammatory factors. Here, NFKB1 is linked to sexually transmitted disease.