CUL3 and systemic sclerosis: Gene expression profiles obtained from the PBMC of patients with SSc indicate an altered modulation of genes involved in apoptosis and in cell proliferation that could, at tissue level, exert a mitogenic effect on some cellular populations or lead to down-modulation of oncosuppressor genes, as suggested by the downregulation of CUL3 (31) in both lSSc and dSSc.