PRMT5 and systemic sclerosis: The upregulation of genes such as chemokine (C-X-C motif) ligand 10 (CXCL10), forkhead box P1(FOXP1), protein arginine methyltransferase 5(PRMT5), and selectin P (SELP) is consistent with the endothelial cells activation that is typical of SSc and is accompanied by the overexpression of cell adhesion molecules involved in endothelial cells and leukocytes interactions as well as in blood cells extravasation.