Chronic inflammation is a feature of SSc; therefore, the upregulation of genes involved in the inflammatory response, including chemokine (C-X-C motif) ligand 10 (CXCL10), chemokine (C-X-C motif) receptor 5 (CXCR5), folate receptor 2 (FOLR2), interleukin 2 receptor, alpha (IL2RA), thromboxane A2 receptor (TBXA2R), and glutathione peroxidase 1 (GPX1), is not surprising. The gene discussed is GPX1; the disease is systemic sclerosis.