Activation via 2 strong stimuli, such as α-GalCer and IL-12, increases iNKT cell IFNγ production, promotes tumor rejection, and protects from development of metastasis in multiple mouse models and enhances cancer patient iNKT Th1 responses in vitro (8, 22, 24, 25, 35). The gene discussed is IFNG; the disease is neoplasm.