There may well be more total “non-invariant” diverse CD1d-restricted NKT cells in the body than iNKT and their ability to make Th2 cytokines appears to impair tumor immunity (30), whereas such NKT making IFNγ stratifies with cancer patient survival (83), as does iNKT (24, 25, 54). The gene discussed is CD1D; the disease is cancer.