Of note, IL-10 but not TNF-α increased the surface CD68 expressions in a concentration-dependent manner (Figures S2A,B in Supplementary Material), which might partly explain the fact that the number of CD68-positve Mφs was markedly increased in the foci of chronic inflammatory diseases like RA (43–46)and a variety of cancer (47–49). This evidence concerns the gene IL10 and cancer.