Through this approach, glypican-1 positive exosomes as well as plasma miR-96-5p and miR-149 are suggested as markers for colorectal cancer diagnosis and therapy evaluation (71) Furthermore, in the case of colorectal cancer patients with peritoneal metastases, it was found that high epithelial versican expression in combination with high vascular endothelial growth factor levels were markers of better response to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, resulting in higher overall survival (72). This evidence concerns the gene VEGFA and colorectal cancer.