Indeed, as recently discussed by Ilieva et al., CSPG4 “has been associated with the pathology of multiple types of cancer such as melanoma, breast cancer, squamous cell carcinoma, mesothelioma, neuroblastoma, adult and pediatric sarcomas, and some hematological cancers” and has become the goal of different, under development, therapeutical strategies (74). This evidence concerns the gene CSPG4 and melanoma.