NOS2 and Alzheimer disease: In a recently developed CVN-AD mouse model, immune-mediated nitric oxide (iNOS) was lowered to mimic human levels, resulting in a model that demonstrates the complete pathological course of AD, including parenchymal amyloidosis, gradual spread of hyperphosphorlyated tau, episodic memory impairment, and significant hippocampal neuronal degeneration (Colton et al., 2008, 2014; Wilcock et al., 2014).