CREB1 and Alzheimer disease: Abnormalities in cognition-related pathways including CREB (Teich et al., 2015), glutamate (Thomas, 1995; Lewerenz and Maher, 2015), and voltage-gated ion channels (Shah and Aizenman, 2014; Kumar P. et al., 2016) have been associated with AD-related cognitive impairment.