This type of stress is associated with other aspects of AD-related pathophysiology as well, including mitochondrial dysfunction, accumulation of redox metals, dysregulation of calcium homeostasis, hyperphosphorylation of tau proteins, Aβ accumulation, synaptic dysfunction, neuroinflammation and neurodegeneration (Mondragón-Rodríguez et al., 2013; Zhao and Zhao, 2013; Tönnies and Trushina, 2017). This evidence concerns the gene MAPT and Alzheimer disease.