ESR1 and Alzheimer disease: This channel appears associated with ERα in neuronal lipid rafts from a wide variety of brain regions, including septum, hippocampus, and cortex from, both, murine and human origins (Marin et al., 2007, 2009; Ramirez et al., 2009), where it participates in different pathogenesis including AD (Thinnes, 2015).