GST-π, a highly inducible phase II detoxification enzyme, is regulated by transcriptional factors including activating protein-1 (AP-1) and nuclear factor erythroid-2-related factor 2 (Nrf2), and functions in detoxifying multiple anti-cancer drugs including chlorambucil, cyclophosphamide, cisplatin, DOX and mitoxantrone [41, 42]. Here, NFE2L2 is linked to cancer.