Firstly, targeted small inhibitors dampening pathologically activated cell-intrinsic signalling mechanisms, with the most effective to date being a combination of BRAF and MEK inhibitors in BRAF-mutated melanoma.32 Secondly, immunotherapies applying anti-CTLA-4 and anti-PD-1 antibodies have shown impressive response rates in cutaneous and mucosal melanoma.33–35 Both approaches may be clinically useful in advanced conjunctival melanoma.36 This evidence concerns the gene BRAF and malignant conjunctival melanoma.