TOP2A and cancer: Accordingly, we found several genetic alterations in promoters, introns, and other non-coding regulatory regions, which can possibly alter the phosphorylation, protein–protein interaction, and regulatory networks involving different cancer-related genes, including ATM/ATR, FGFR1, FOXA1, IGF1R, NF1, NOTCH2 and TOP2A (Supplementary Table 5).