Finally, we reported different variants that can be responsible of motif-breaking events or gain of new binding sites for TFs that can potentially constitute functionally relevant driver events, especially when occurring in cancer-associated genes, such as AKT2, CDKN1B, ERBB2, FBXO11, NF1, PTCH1 and TP53 (Table 1 and Supplementary Table 5). Here, PTCH1 is linked to cancer.