Several studies have attempted to investigate the prognostic relevance of somatic mutations within single genes in breast cancer, mainly TP53 and PIK3CA. 18–20 However, a clinically useful association between gene mutations and outcome has not been clearly demonstrated so far.2 Accordingly, we demonstrated that single genetic alterations in coding and non-coding regions have no prognostic value in breast cancer. The gene discussed is TP53; the disease is breast cancer.