PFKFB3 and hepatocellular carcinoma: To explore the clinical significance of PFKFB3 in HCC, we first performed a Kaplan–Meier survival analysis based on the data of The Cancer Genome Atlas (TCGA), which included 374 HCC patients divided into two groups with high or low expressions of PFKFB3 according to the median value of PFKFB3 expression.