Altogether, our results reveal an important role for SOCS2 dysregulation in the pathogenicity of lung adenocarcinoma, suggest its potential use as a biomarker for diagnosing lung adenocarcinoma, and paves the way to develop novel therapy targets as the axis of SOCS2–IGF1R–STAT in lung adenocarcinoma. The gene discussed is SOAT1; the disease is lung adenocarcinoma.