Furthermore, IGF1 treatment could not effectively decrease E-cadherin protein levels and increase the expression of mesenchymal markers in A549-SOCS2 and SPC-A1-SOCS2 cells (Fig. 5d), indicating that SOCS2 is involved in the regulation of IGF1-induced EMT in lung adenocarcinoma cells. The gene discussed is IGF1; the disease is lung adenocarcinoma.