Considering that the low expression of SOCS2 in NSCLC, HNSCC, hepatocellular carcinoma, and oral squamous cell carcinoma with distant metastasis and that the overwhelming majority of NSCLC patients succumb to their disease as a result of distant metastasis, our study suggests a promising therapeutic target for lung adenocarcinoma in clinical practice and probably in the other malignant tumours. This evidence concerns the gene SOCS2 and oral cavity squamous cell carcinoma.