IGF1R and lung adenocarcinoma: To determine whether SOCS2 associates with IGF1R in lung adenocarcinoma cells, immunoprecipitation was performed and as shown in Fig. 5a and Supplementary Figure S6a, an increase in SOCS2 expression corresponded to an increased association between SOCS2 and IGF1R; however, no interaction was observed between SOCS2 and JAK (Supplementary Figure S6b).