Another group found that Huh7 hepatoma cells cotreated with IFN-α and IL-1β show potentiated ISG expression and phosphorylation of STAT1, while no ISG induction was observed upon the treatment of cells with IL-1β alone (40); these results suggest that the IFN–IL-1β combination might provide promoter enhanceosome activity through specific transcription factors that together drive enhanced ISG expression in these cells (63). The gene discussed is IFNA1; the disease is hepatocellular carcinoma.