BRD7 and nasopharyngeal carcinoma: However, overexpression of c-Myc could not change the expression and the promoter activity of BRD7 in 5-8F and HNE1 cells (Additional file 2: Figure S2 h, i and j), suggesting that the high level of endogenous c-Myc is sufficient to inactivate the transcription of BRD7 in NPC cells.