It has also been reported that HMGA1 can bind the Rbp4 promoter and recruit the transcription factors steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1) to form an activation complex and induce Rbp4 transcription in Hepa1 mouse hepatoma cells [22]. This evidence concerns the gene RBP4 and hepatocellular carcinoma.