In particular in lung cancer, it has been suggested that CAF-produced IL-6 regulates chemoresistance [43] and stromal-derived TGFβ and IGF-II have both been shown to induce EMT and regulate stemness properties of cancer cells [30, 44], but little is known about the mechanisms underlying the modification of fibroblast secretome. The gene discussed is TGFB1; the disease is cancer.