According to our results, RUNX2 gene silencing increased GEM sensitivity of p53-null pancreatic cancer AsPC-1 cells [21] as well as p53-mutated pancreatic cancer MiaPaCa-2 and Panc-1 cells [22, 23], raising a possibility that RUNX2 depletion improves GEM sensitivity of pancreatic cancer cells without functional p53. The gene discussed is RUNX2; the disease is familial pancreatic carcinoma.