Although it is unknown whether miRNA-mediated down-regulation of RUNX2 could lead to the potentiation of TAp73/TAp63-dependent cell death pathway, RUNX2 silencing-mediated restoration of TAp73/TAp63 and down-regulation of its pro-oncogenic downstream target genes might represent a promising approach to override the serious drug-resistant phenotype of pancreatic cancer with p53 mutation. This evidence concerns the gene RUNX2 and familial pancreatic carcinoma.