Among HIV+ persons, nadir CD4 count <200 cells/mm3 was associated with approximately two-fold greater odds of AF/AFL; this persisted even after adjustment for age, sex, race, BMI, diabetes, hypertension, smoking, and COPD (Table 3; adjusted OR 1.98, 95% CI 1.21–3.25). This evidence concerns the gene CD4 and chronic obstructive pulmonary disease.