Low whole grains consumption, metabolically healthy obesity, increased sedentary time, low adherence to a healthy dietary pattern, high level of serum uric acid, low level of serum vitamin D, decreased conscientiousness, preterm birth, high consumption of sugar-sweetened beverages, high level of serum ALT, and exposure to high level of PM10 were associated with increased risk for T2DM and supported by convincing evidence. Here, GPT is linked to obesity due to melanocortin 4 receptor deficiency.