In one of the studies exploring the role of p53 in the immune response arising in HCC, embryonic liver progenitor cells transduced with retroviruses expressing H-RasV12 oncogene and p53 shRNA driven by a tet-off promoter were transplanted into adult livers of athymic nude mice [116] or injected subcutaneously into Rag2−/− mice [117]. The gene discussed is TP53; the disease is hepatocellular carcinoma.