In previous studies, M-M combined with BCG induced the Th1 dominant immune response, NK cell activity, MUC1-specific cytotoxic T lymphocyte (CTL) killing activity, and mouse MUC1 expression B16 cell (B16-MUC1) growth inhibition, but induced arthritis or local nodules in rats and cynomolgus monkeys [14,15]. This evidence concerns the gene MUC1 and arthritic joint disease.