DNA-dependent activator of IFN-regulatory factors (DAI), absent in melanoma 2 (AIM2), gamma interferon-inducible protein 16 (IFI16), and cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP synthase; cGAS) are the major cytosolic DNA sensors involved in innate immune responses, following viral infection [164,165,166,167,168,169]. Here, IFI16 is linked to viral infectious disease.