DUSP1 plays an important role in cell proliferation, cycle arrest, differentiation, transformation and apoptosis [139], and is involved in development and progression of many cancers such as prostatic cancer [140], pancreatic cancer [141], lung cancer [142], breast cancer [143] and gastric cancer [144], head and neck squamous cell carcinoma [145] and gallbladder cancer [146]. This evidence concerns the gene DUSP1 and head and neck squamous cell carcinoma.