Recently, pituitary homeobox 1 (PITX1) was reported to act as a tumor suppressor in hepatocarcinogenesis by activating the expression of p120RasGAP (also known as Ras p21 protein activator 1 (RASA1)), triggering Ras inactivation by converting GTP into GDP [60]. The gene discussed is PITX1; the disease is neoplasm.