Among the 16 reported PTPs involved in HCC, most of them act as tumor suppressor, e.g., PTPRD, PTPRF, PTPRH, PTPRO, PTPRS, PTPRT, PTPN9, PTPNN12, PTPN13, SHP-1 and DUSP1. The gene discussed is PTPRF; the disease is hepatocellular carcinoma.