The Sig1R expression was analyzed in lysates from melanoma (A375), squamous cell/epidermoid carcinoma (FaDu, A431), prostate carcinoma (DU145, PC3), glioblastoma (U87-MG), and lung carcinoma (NCI-H292) cells grown in vitro in cell culture as well as in mouse heterotopic tumor. The gene discussed is SIGMAR1; the disease is squamous cell carcinoma.