The Hupki mice carrying codon 72 SNP recapture the impacts of codon 72 SNP upon p53 transcriptional activity and function in tumor suppression, which is widely used for studies on p53 and codon 72 SNP (Feng et al., 2011; Kung et al., 2016; Azzam et al., 2011; Reinbold et al., 2008; Frank et al., 2011; Leu et al., 2013). This evidence concerns the gene TP53 and neoplasm.