LMNA and progeroid syndrome: Studying mutant lamin structure at the higher resolution cryo-EM was performed on 4 mutations: Q159K (progeria; E145K in LMNA), T164P (EDMD, T150P in LMNA), L535P (EDMD, L530P in LMNA) and deltaK46 (EDMD, deltaK32 in LMNA) [45, 46] (Fig. 1).