ANG and hypertensive disorder: It was found that administration of Ang-(1-7), either ICV or into the nucleus of the solitary tract (NTS), induces hypotensive and bradycardic effects and facilitates baroreflex bradycardia, whereas the intrabrain administration of Ang-(1-7) antibody in transgenic hypertensive rats induces tachycardia and hypertension [105, 106•].