The elevated release of AVP plays a major role in the development of hypertension in mice with brain-specific hyperactivity of the renin and angiotensinogen genes as it has been shown that the baseline blood pressure can be normalized in this strain by the administration of the nonselective AVP receptor antagonist conivaptan or the V2-selective antagonist tolvaptan [335•]. The gene discussed is AGT; the disease is hypertensive disorder.