Administration of Ang-(1-7) antagonist accelerated and intensified development of hypertension in the two-kidney, one-clip Goldblatt model [109•] and Mas knockout mice manifested reduced diuresis and natriuresis, and this was associated with glomerular hyperfiltration and increase of collagen III and fibronectin content in the mesangium and interstitium. Here, ANG is linked to hypertensive disorder.