Expression of AT1R is elevated in SHR arterial vessels, in the brain and hearts of rats with 2K-1C hypertension, and in various brain regions [paraventricular nucleus (PVN), rostral ventrolateral medulla (RVLM), SFO] of hypertensive or myocardially infarcted rats and of rats exposed to oxidative stress or drastic acute and mild chronic stress [29, 59–65]. The gene discussed is AGTR1; the disease is Hypertension.